For his undergraduate studies, John attended the University of Richmond, where he pursued organic chemistry research in the laboratory of Dr. John Gupton. John then completed his thesis research in the laboratory of Dr. Young Hahn at the University of Virginia. In the Hahn lab, his research was focused on identifying immunoregulatory pathways that suppress immune responses in the liver and contribute to functional exhaustion of intrahepatic T cells. For his postdoctoral training, John worked in the laboratory of Dr. Thirumala-Devi Kanneganti at St. Jude Children’s Research Hospital in Memphis. His work defined novel roles for IL-1 signaling pathways in a number of autoinflammatory disorders. In Fall 2014, John returned to the University of Virginia to start his lab in the Department of Neuroscience and the Center for Brain Immunology and Glia (BIG). His laboratory investigates roles for the innate immune response and microbiota in the pathogenesis of multiple sclerosis, traumatic brain injury, neurodegenerative disease, and autism spectrum disorder.