Jorge I. Alvarez PhD

Jorge I. Alvarez, PhD, is an assistant professor of Pathobiology at the University
of Pennsylvania. His laboratory aims to understand the role of the Central
Nervous System (CNS) barriers in regulating immune cell function in
homeostasis and disease. These barriers selectively restrict the molecular and
cellular trafficking between the periphery and the CNS, but are also a signaling
interface actively regulating exchange between both compartments. Dr. Alvarez
has demonstrated that these barriers and their surrounding microenvironment
are fundamental in regulating barrier function and the development of
inflammatory responses within the CNS as seen in Multiple Sclerosis and
Schizophrenia. Currently, his studies are directed to determine the impact of
glial-derived factors on the CNS barriers and on the function of immigrating and
resident immune cells populations during neuroinflammation.