Nathalie Arbour PhD

Nathalie Arbour obtained her Ph.D. in Virology and Immunology at INRS-Armand-Frappier in Quebec, Canada. She completed post-doctoral training at the Scripps Research Institute in the laboratory of Dr. Michael B.A. Oldstone and subsequently at the Montreal Neurological Institute in the team of Dr. Jack Antel. Since 2006, she is professor at Université de Montreal and researcher at Centre de Recherche du CHUM (Université de Montreal affiliated hospital). Her research program aims at characterizing and understanding the interactions between the immune system and the central nervous system (CNS), especially the roles of T cells in the context of multiple sclerosis (MS). Her research strategy is to first identify molecules or mechanisms that are specifically altered in human samples obtained from MS patients. Then, her team investigates the mechanistic impact of such factors using primary cultures of human immune and CNS cells. Finally, using relevant animal models of MS, Nathalie Arbour and her team confirm and dissect the role played by these identified mechanisms and test in vivo strategies to correct these altered factors and thus validate them as bona fide therapeutic targets. The Arbour’s team performs mechanistic studies on human cells as well as on relevant animal models using a wide array of complementary techniques including multiparametric flow cytometry, western blot, qRT-PCR, co-culture systems, and immunohistochemistry. Nathalie Arbour has published more than 56 papers building on data obtained from both human and mouse systems. Her research program is funded by the Multiple Sclerosis Society of Canada, the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.